Edmond J LaVoie : rechercher sur Z-Library

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1

5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-Targeting anticancer agents with potent cytotoxic activity

Alexander L. Ruchelman, Sudhir K. Singh, Abhijit Ray, Xiao Hua Wu, Jin-Ming Yang, Tsai-Kun Li, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 450 KB

english, 2003

2

Bioisosterism: A Rational Approach in Drug Design

Patani, George A., LaVoie, Edmond J.

Journal:

Chemical Reviews

Année:

1996

Langue:

english

Fichier:

PDF, 914 KB

english, 1996

3

Mutagenicity of aminocarbazoles and nitrocarbazoles

Edmond J. LaVoie, Alok Govil, Georganne Briggs, Dietrich Hoffmann

Journal:

Mutation Research/Genetic Toxicology

Année:

1981

Langue:

english

Fichier:

PDF, 331 KB

english, 1981

4

Antioxidative Phenolic Compounds from Sage ( Salvia officinalis )

Wang, Mingfu, Li, Jiangang, Rangarajan, Meera, Shao, Yu, LaVoie, Edmond J., Huang, Tzou-Chi, Ho, Chi-Tang

Journal:

Journal of Agricultural and Food Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 110 KB

english, 1998

5

Crystallographic Fragment Screening and Structure-Based Optimization Yields a New Class of Influenza Endonuclease Inhibitors

Bauman, Joseph D., Patel, Disha, Baker, Steven F., Vijayan, R. S. K., Xiang, Amy, Parhi, Ajit K., Martínez-Sobrido, Luis, LaVoie, Edmond J., Das, Kalyan, Arnold, Eddy

Journal:

ACS Chemical Biology

Année:

2013

Langue:

english

Fichier:

PDF, 1.49 MB

english, 2013

6

ChemInform Abstract: Nitroarylstannanes as Synthons for the Preparation of Phenanthridine and Benzo[i]phenantridine Derivatives.

Dajie Li, Baoping Zhao, Edmond J. LaVoie

Journal:

Année:

2000

Fichier:

PDF, 30 KB

2000

7

Diaza- and Triazachrysenes: Potent Topoisomerase-Targeting Agents with Exceptional Antitumor Activity Against the Human Tumor Xenograft, MDA-MB-435

Alexander L. Ruchelman, Sudhir K. Singh, Xiaohua Wu, Abhijit Ray, Jin-Ming Yang, Tsai-Kun Li, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Année:

2003

Fichier:

PDF, 134 KB

2003

8

Mutagenic activity of the 4,5- and 9,10-dihydrodiols of benzo[J]fluoranthene and their syn- and anti-dihydrodiol epoxides in salmonella typhimurium

Milton V. Marshall, Zhen-Min He, Eric H. Weyand, Joseph E. Rice, Edmond J. Lavoie

Journal:

Environmental and Molecular Mutagenesis

Année:

1993

Langue:

english

Fichier:

PDF, 908 KB

english, 1993

9

Synthesis of [methoxy-14C]eugenol

Joseph E. Rice, Nalband Hussain, Edmond J. Lavoie

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Année:

1987

Langue:

english

Fichier:

PDF, 254 KB

english, 1987

10

11H-Isoquino[4,3-c]cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity

Alexander L Ruchelman, Sudhir K Singh, Abhijit Ray, Xiaohua Wu, Jin-Ming Yang, Nai Zhou, Angela Liu, Leroy F Liu, Edmond J LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 373 KB

english, 2004

11

Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity

Alexander L Ruchelman, John E Kerrigan, Tsai-Kun Li, Nai Zhou, Angela Liu, Leroy F Liu, Edmond J LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 637 KB

english, 2004

12

Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: Potent cytotoxic and topoisomerase I-targeting agents

Shejin Zhu, Alexander L. Ruchelman, Nai Zhou, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 256 KB

english, 2005

13

6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: Reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity

Shejin Zhu, Alexander L. Ruchelman, Nai Zhou, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2006

Langue:

english

Fichier:

PDF, 238 KB

english, 2006

14

Coralyne and related compounds as mammalian topoisomerase I and topoisomerase II poisons

Darshan Makhey, Barbara Gatto, Chiang Yu, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 1.22 MB

english, 1996

15

Structure-activity relationships of benzimidazoles and related heterocycles as topoisomerase I poisons

Jung Sun Kim, Qun Sun, Barbara Gatto, Chiang Yu, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

1996

Langue:

english

Fichier:

PDF, 1.04 MB

english, 1996

16

Syntheses and biological evaluation of topoisomerase I-targeting agents related to 11-[2-(N,N-dimethylamino)ethyl]-2,3-dimethoxy-8,9-methylenedioxy-11H-isoquino[4,3-c]cinnolin-12-one (ARC-31)

Mavurapu Satyanarayana, Wei Feng, Liang Cheng, Angela A. Liu, Yuan-Chin Tsai, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 224 KB

english, 2008

17

11-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridine derivatives as novel topoisomerase I-targeting agents

Wei Feng, Mavurapu Satyanarayana, Yuan-Chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 223 KB

english, 2008

18

Synthesis of N-substituted 5-[2-(N-alkylamino)ethyl]dibenzo[c,h][1,6]naphthyridines as novel topoisomerase I-targeting antitumor agents

Wei Feng, Mavurapu Satyanarayana, Liang Cheng, Angela Liu, Yuan-Chin Tsai, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 383 KB

english, 2008

19

12-Substituted 2,3-dimethoxy-8,9-methylenedioxybenzo[i]phenanthridines as novel topoisomerase I-targeting antitumor agents

Wei Feng, Mavurapu Satyanarayana, Yuan-Chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 488 KB

english, 2009

20

Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity

Alexander L. Ruchelman, Shejin Zhu, Nai Zhou, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2004

Langue:

english

Fichier:

PDF, 275 KB

english, 2004

21

Synthesis and G-quadruplex stabilizing properties of a series of oxazole-containing macrocycles

Gurpreet Singh Minhas, Daniel S. Pilch, John E. Kerrigan, Edmond J. LaVoie, Joseph E. Rice

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2006

Langue:

english

Fichier:

PDF, 152 KB

english, 2006

22

Lysinyl macrocyclic hexaoxazoles: Synthesis and selective G-quadruplex stabilizing properties

Suzanne G. Rzuczek, Daniel S. Pilch, Edmond J. LaVoie, Joseph E. Rice

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 263 KB

english, 2008

23

Facile formation of hydrophilic derivatives of 5H-8,9-dimethoxy-5-[2-(N,N-dimethylamino)ethyl]-2,3-methylenedioxydibenzo[c,h] [1,6]naphthyridin-6-one (ARC-111) and its 12-aza analog via quaternary ammonium intermediates

Wei Feng, Mavurapu Satyanarayana, Yuan-chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 168 KB

english, 2008

24

Ring-closing metathesis for the synthesis of a highly G-quadruplex selective macrocyclic hexaoxazole having enhanced cytotoxic potency

Mavurapu Satyanarayana, Suzanne G. Rzuczek, Edmond J. LaVoie, Daniel S. Pilch, Angela Liu, Leroy F. Liu, Joseph E. Rice

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2008

Langue:

english

Fichier:

PDF, 248 KB

english, 2008

25

Macrocyclic hexaoxazoles: Influence of aminoalkyl substituents on RNA and DNA G-quadruplex stabilization and cytotoxicity

Mavurapu Satyanarayana, Young-Ah Kim, Suzanne G. Rzuczek, Daniel S. Pilch, Angela A. Liu, Leroy F. Liu, Joseph E. Rice, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2010

Langue:

english

Fichier:

PDF, 469 KB

english, 2010

26

Novel topoisomerase I-targeting antitumor agents synthesized from the N,N,N-trimethylammonium derivative of ARC-111, 5H-2,3-dimethoxy-8,9-methylenedioxy-5-[(2-N,N,N-trimethylammonium)ethyl]dibenzo[c,h][1,6]naphthyridin-6-one iodide

Wei Feng, Mavurapu Satyanarayana, Yuan-Chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

European Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 209 KB

english, 2009

27

Heterocyclic bibenzimidazole derivatives as topoisomerase I inhibitors

Song Jin, Jung Sun Kim, Sai-Peng Sim, Angela Liu, Daniel S. Pilch, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2000

Langue:

english

Fichier:

PDF, 150 KB

english, 2000

28

Structure activity of topoisomerase i poisons related to hoechst 33342

Qun Sun, Barbra Gatto, Chiang Yu, Angela Liu, Leory F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

1994

Langue:

english

Fichier:

PDF, 361 KB

english, 1994

29

5H-8,9-Dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h]naphthyridin-6-ones and related compounds as TOP1-Targeting agents: influence of structure on the ternary cleavable complex formation

John E. Kerrigan, Daniel S. Pilch, Alexander L. Ruchelman, Nai Zhou, Angela Liu, Leroy Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 318 KB

english, 2003

30

Substituted benz[a]acridines and benz[c]acridines as mammalian topoisomerase poisons

Darshan Makhey, Chiang Yu, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 329 KB

english, 2000

31

2″-Substituted 5-phenylterbenzimidazoles as topoisomerase I poisons

Meera Rangarajan, Jung Sun Kim, Song Jin, Sai-Peng Sim, Angela Liu, Daniel S. Pilch, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 282 KB

english, 2000

32

Topoisomerase I inhibition and cytotoxicity of 5-Bromo- and 5-Phenylterbenzimidazoles

Meera Rangarajan, Jung Sun Kim, Sai-Peng Sim, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 219 KB

english, 2000

33

Antineoplastic activity of benzimidazo[1,2-b]-isoquinolines, indolo[2,3-b]quinolines, and pyridocarbazoles

Ronni L. Weinkauf, Allan Y. Chen, Chiang Yu, Leroy Liu, Louis Barrows, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

1994

Langue:

english

Fichier:

PDF, 850 KB

english, 1994

34

2,3-Dimethoxybenzo[i]phenanthridines: topoisomerase I-targeting anticancer agents

Dajie Li, Baoping Zhao, Sai-Peng Sim, Tsai-Kun Li, Angela Liu, Leroy F Liu, Edmond J LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 256 KB

english, 2003

35

8,9-Methylenedioxybenzo[i]phenanthridines: Topoisomerase I-Targeting activity and cytotoxicity

Dajie Li, Baoping Zhao, Sai-Peng Sim, Tsai-Kun Li, Angela Liu, Leroy F Liu, Edmond J LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 345 KB

english, 2003

36

Quantitative structure–activity relationships on 5-substituted terbenzimidazoles as topoisomerase I poisons and antitumor agents

Jung Sun Kim, Qun Sun, Chiang Yu, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

1998

Langue:

english

Fichier:

PDF, 182 KB

english, 1998

37

Toxicity studies on clove cigarette smoke and constituents of clove: determination of the LD50of eugenol by intratracheal instillation in rats and hamsters

Edmond J. LaVoie, John D. Adams, Joel Reinhardt, Abraham Rivenson, Dietrich Hoffmann

Journal:

Archives of Toxicology

Année:

1986

Langue:

english

Fichier:

PDF, 443 KB

english, 1986

38

Comments on the toxicity of constituents in clove cigarette smoke

Edmond J. LaVoie, John D. Adams, Joel Reinhardt, Abraham Rivenson, Dietrich Hoffmann

Journal:

Archives of Toxicology

Année:

1986

Langue:

english

Fichier:

PDF, 131 KB

english, 1986

39

Cytotoxicity and TOP1-targeting activity of 8- and 9-amino derivatives of 5-butyl- and 5-(2-N,N-dimethylamino)ethyl-5H-dibenzo[c,h][1,6]naphthyridin-6-ones

Lisa Sharma, Yuan-Chin Tsai, Angela A. Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

European Journal of Medicinal Chemistry

Année:

2009

Langue:

english

Fichier:

PDF, 261 KB

english, 2009

40

Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435

Alexander L. Ruchelman, Sudhir K. Singh, Xiaohua Wu, Abhijit Ray, Jin-Ming Yang, Tsai-Kun Li, Angela Liu, Leroy F. Liu, Edmond J. LaVoie

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2002

Langue:

english

Fichier:

PDF, 148 KB

english, 2002

41

Substituted dibenzo[c,h]cinnolines: topoisomerase I-targeting anticancer agents

Younong Yu, Sudhir K Singh, Angela Liu, Tsai-Kun Li, Leroy F Liu, Edmond J LaVoie

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 396 KB

english, 2003

42

ANTIOXIDATIVE FLAVONOID GLYCOSIDES FROM QUINOA SEEDS (CHENOPODIUM QUINOA WILLD)

NANQUN ZHU, SHUQUN SHENG, DAJIE LI, EDMOND J. LAVOIE, MUKUND V. KARWE, ROBERT T. ROSEN, CHI-TANG HO

Journal:

Journal of Food Lipids

Année:

2001

Langue:

english

Fichier:

PDF, 375 KB

english, 2001

43

Nitro and Amino Substitution in the D-Ring of 5-(2-Dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: Effect on Topoisomerase-I Targeting Activity and Cytotoxicity

Singh, Sudhir K., Ruchelman, Alexander L., Li, Tsai-Kun, Liu, Angela, Liu, Leroy F., LaVoie, Edmond J.

Journal:

Journal of Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 85 KB

english, 2003

44

Studies on the mutagenicity and tumor-initiating activity of methylated fluorenes

Edmond J. Lavoie, Daniel T. Coleman, Nora G. Geddie, Joseph E. Rice

Journal:

Chemico-Biological Interactions

Année:

1985

Langue:

english

Fichier:

PDF, 471 KB

english, 1985

45

Identification of metabolites of benzo[j]fluoranthene formed in vitro in rat liver homogenate

Joseph E. Rice, Nora G. Geddie, Edmond J. Lavoie

Journal:

Chemico-Biological Interactions

Année:

1987

Langue:

english

Fichier:

PDF, 588 KB

english, 1987

46

The influence of fluoranthene on the metabolism and DNA binding of benzo[a]pyrene in vivo in mouse skin

Joseph E. Rice, Marianne C. Defloria, Carlo Sensenhauser, Edmond J. Lavoie

Journal:

Chemico-Biological Interactions

Année:

1988

Langue:

english

Fichier:

PDF, 567 KB

english, 1988

47

Effects of fluorine substitution on the DNA binding and tumorigenicity of benzo[b]fluoranthene in mouse epidermis

Eric H. Weyand, Shantu Amin, Keith Huie, Eliahu Boger, Evelyn Neuber, Stephen S. Hecht, Edmond J. LaVoie

Journal:

Chemico-Biological Interactions

Année:

1989

Langue:

english

Fichier:

PDF, 948 KB

english, 1989

48

Evaluation of the tumor-initiating activity of 4-, 5-, 6-, and 7-fluorobenzo[b]fluoranthene in mouse skin

Edmond J. LaVoie, Zhen-Wei Cai, Rupalie L. Meegalla, Eric H. Weyand

Journal:

Chemico-Biological Interactions

Année:

1993

Langue:

english

Fichier:

PDF, 568 KB

english, 1993

49

The influence of methyl substitution on the mutagenicity of nitronaphthalenes and nitrobiphenyls

Karam El-Bayoumy, Edmond J. Lavoie, Stephen S. Hecht, Elizabeth Ann Fow, Dietrich Hoffmann

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

1981

Fichier:

PDF, 424 KB

1981

50

Mutagenicity of methylated fluorenes and benzofluorenes

Edmond J. Lavoie, Lorraine Tulley, Victoria Bedenko, Dietrich Hoffmann

Journal:

Mutation Research Letters

Année:

1981

Langue:

english

Fichier:

PDF, 366 KB

english, 1981